Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals.

Anjali M Byappanahalli Nicole Noren HootenMya VannoyNicolle A ModeNgozi EzikeAlan B ZondermanMichele Kim Evans

Published in: Immunity & ageing : I & A (2023)

These data suggest that mtDNA within EVs may act as a DAMP molecule in frailty. Its association with chemokines and other inflammatory EV cargo proteins, may contribute to the frailty phenotype. In addition, the social determinant of health, poverty, influences the inflammatory cargo of EVs in midlife.

Keyphrases

mitochondrial dna
copy number
oxidative stress
healthcare
community dwelling
mental health
public health
gene expression
genome wide
human health
artificial intelligence
health promotion