LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice.
Xingxian GuoJiangxia PuZiqi TangCan JiaFan YangTianyi LiuYinyuan DingPublished in: Animal models and experimental medicine (2024)
Our data revealed that LRP1, especially its β-chain, facilitates hepatic glycogenesis by improving the insulin signaling pathway, suggesting a new therapeutic strategy for hepatic insulin resistance-related diseases.
Keyphrases
- signaling pathway
- type diabetes
- insulin resistance
- pi k akt
- high fat diet
- high fat diet induced
- glycemic control
- epithelial mesenchymal transition
- adipose tissue
- induced apoptosis
- metabolic syndrome
- electronic health record
- big data
- machine learning
- cell proliferation
- polycystic ovary syndrome
- endoplasmic reticulum stress
- low density lipoprotein
- drug induced