Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity.
Ai-Ci ChanPei-Ya ShanMen-Hsin WuPin-Han LinChang-Shun TsaiChia-Chien HsuTing-Hsiang ChiuTing-Wei HsuYi-Cheun YehYun-Ju LaiWei-Min LiuLing-Hsien TuPublished in: Chemical communications (Cambridge, England) (2023)
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.
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