Purine Metabolism in Platelets and Heart Cells of Hyperlipidemic Rats.

A G ManzoniD F PassosP H DoleskiJ W LeitempergerV L LoroDaniela Bitencourt Rosa Leal

Published in: Cardiovascular drugs and therapy (2020)

Together, these findings are indicative of an increased risk of developing cardiovascular diseases in hyperlipidemic rats. The pretreatments with antioxidants reverted some of the changes prompted by hyperlipidemia preventing detrimental changes in the cells and tissues. Graphical Abstract.

Keyphrases

induced apoptosis
cell cycle arrest
cardiovascular disease
heart failure
gene expression
endoplasmic reticulum stress
oxidative stress
cell death
high fat diet
cardiovascular risk factors
cardiovascular events
high fat diet induced