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Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.

Ester Cerdeira SabinoLucas Augusto Moysés FrancoGabriela VenturiniMariliza Velho RodriguesEmanuelle MarquesLea Campos de Oliveira-da SilvaLarissa Natany Almeida MartinsAriela Mota FerreiraPaulo Emílio Clementino AlmeidaFelipe Dias Da SilvaSâmara Fernandes LeiteMaria do Carmo Pereira NunesDesiree Sant'Ana HaikalClaudia Di Lorenzo OliveiraClareci Silva CardosoJonathan G SeidmanChristine E SeidmanJuan P CasasAntonio Luiz Pinho RibeiroJose E KriegerAlexandre da Costa Pereira
Published in: PLoS neglected tropical diseases (2022)
We suggest that the newly identified locus impacts CCC risk among T cruzi infected individuals through the modulation of a downstream transcriptional and protein signature associated with host-parasite immune response. Functional characterization of the novel risk locus is warranted.
Keyphrases
  • genome wide association study
  • immune response
  • gene expression
  • heart failure
  • transcription factor
  • dendritic cells
  • inflammatory response
  • trypanosoma cruzi
  • heat stress