Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.
Ester Cerdeira SabinoLucas Augusto Moysés FrancoGabriela VenturiniMariliza Velho RodriguesEmanuelle MarquesLea Campos de Oliveira-da SilvaLarissa Natany Almeida MartinsAriela Mota FerreiraPaulo Emílio Clementino AlmeidaFelipe Dias Da SilvaSâmara Fernandes LeiteMaria do Carmo Pereira NunesDesiree Sant'Ana HaikalClaudia Di Lorenzo OliveiraClareci Silva CardosoJonathan G SeidmanChristine E SeidmanJuan P CasasAntonio Luiz Pinho RibeiroJose E KriegerAlexandre da Costa PereiraPublished in: PLoS neglected tropical diseases (2022)
We suggest that the newly identified locus impacts CCC risk among T cruzi infected individuals through the modulation of a downstream transcriptional and protein signature associated with host-parasite immune response. Functional characterization of the novel risk locus is warranted.