Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals.

Christian HerzmannMartin ErnstChristoph LangeSteffen StengerStefan H E KaufmannNorbert ReilingTom SchabergLize van der MerweJeroen Maertzdorfnull null

Published in: PloS one (2017)

In vitro BAL cell cytokine responses to M. tuberculosis antigens or infection do not reflect blood IGRA status but do correlate with stronger cellular responses in BAL IGRA-positive donors. The cytokine patterns observed suggest a pre-activated state of lymphocytes and suppressed macrophage responsiveness in BAL cells from BAL IGRA-positive individuals.

Keyphrases

mycobacterium tuberculosis
immune response
pulmonary tuberculosis
pulmonary hypertension
single cell
dendritic cells
cell therapy
adipose tissue
mesenchymal stem cells
kidney transplantation
bone marrow