3D-printed nerve guidance conduits multi-functionalized with canine multipotent mesenchymal stromal cells promote neuroregeneration after sciatic nerve injury in rats.

Diego Noé Rodríguez-SánchezGiovana Boff Araujo PintoLuciana Politti CartarozziAlexandre Leite Rodrigues de OliveiraAna Livia Carvalho BovolatoMarcio de CarvalhoJorge Vicente Lopes da SilvaJanaina de Andréa DernowsekMarjorie GolimBenedito BarravieraRui Seabra FerreiraElenice DeffuneMathues BertanhaRogério Martins Amorim

Published in: Stem cell research & therapy (2021)

3D-printed NGCs multi-functionalized with canine AdMSCs embedded in heterologous fibrin biopolymer as cell scaffold exerted neuroregenerative effects. Our multimodal approach supports the trophic microenvironment, resulting in a pro-regenerative state after critical sciatic nerve injury in rats.

Keyphrases

stem cells
cell therapy
quantum dots
tissue engineering
single cell
mesenchymal stem cells
bone marrow
pain management
anti inflammatory
peripheral nerve