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Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism.

Changmeng CuiChangshui WangFeng JinMengqi YangLingsheng KongWenxiu HanPei Jiang
Published in: Molecular medicine (Cambridge, Mass.) (2021)
Therefore, our work demonstrated a neuroprotective role of calcitriol in TBI by triggering Nrf2 activation, which might be mediated by autophagy.
Keyphrases
  • oxidative stress
  • signaling pathway
  • cell death
  • endoplasmic reticulum stress
  • traumatic brain injury
  • spinal cord injury
  • cerebral ischemia
  • white matter
  • subarachnoid hemorrhage
  • brain injury
  • blood brain barrier