Whole-exome sequencing reveals novel cancer genes and actionable targets in biliary tract cancers in primary sclerosing cholangitis.
Marit M GrimsrudMichael ForsterBenjamin GoeppertGeorg Hemmrich-StanisakIrmi SaxKrzysztof GrzybPeder R BraadlandAlphonse CharbelCarmen MetzgerThomas AlbrechtTim Alexander SteiertMatthias SchlesnerMichael P MannsArndt VogelSheraz YaqubTom Hemming KarlsenPeter SchirmacherKirsten M BobergAndre FrankeStephanie RoesslerTrine FolserassPublished in: Hepatology communications (2024)
In this exome-wide characterization of PSC-associated BTC, we delineated both PSC-specific and universal cancer genes. Our findings provide opportunities for a better understanding of the development of BTC in PSC and could be used as a platform to develop personalized treatment approaches.