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Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations.

Joseph S ReddyLaura HeathAbby Vander LindenMariet AllenKatia de Paiva LopesFatemeh SeifarErming WangYiyi MaWilliam L PoehlmanZachary S QuicksallAlexi RunnelsYanling WangDuc M DuongLuming YinKaiming XuErica S ModesteAnantharaman ShantaramanEric B DammerLingyan PingStephanie R OatmanJo ScanlanCharlotte HoMinerva M CarrasquilloMerve AtikGeovanna YepezAdriana O MitchellThuy T NguyenXianfeng ChenDavid X MarquezHasini ReddyHarrison XiaoSudha SeshadriRichard MayeuxStefan ProkopEdward B LeeGeidy E SerranoThomas G BeachAndrew F TeichVarham HaroutunianEdward J FoxMarla GearingAliza WingoThomas WingoJames J LahAllan I LeveyDennis W DicksonLisa L BarnesPhilip De JagerBin ZhangDavid BennettNicholas T SeyfriedAnna K GreenwoodNilüfer Ertekin-Taner
Published in: bioRxiv : the preprint server for biology (2024)
Inclusion of traditionally underrepresented groups in multi-omics studies is essential to discover the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.
Keyphrases
  • single cell
  • physical activity
  • cognitive decline
  • multiple sclerosis
  • middle aged
  • community dwelling
  • blood brain barrier
  • cerebral ischemia