Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence.

Shuming ZhangLong YuanLudmila DanilovaGuanglan MoQingfeng ZhuAtul DeshpandeAlexander T F BellJennifer ElisseeffAleksander S PopelRobert A AndersElizabeth M JaffeeMark YarchoanElana J FertigLuciane Tsukamoto Kagohara

Published in: Genome medicine (2023)

These data show that responses to modern systemic therapy in HCC are associated with distinctive molecular and cellular landscapes and provide new targets to enhance and prolong responses to systemic therapy in HCC.

Keyphrases

rectal cancer
lymph node
genome wide
electronic health record
locally advanced
squamous cell carcinoma
gene expression
big data
machine learning
single molecule
drug induced
bone marrow
artificial intelligence
metastatic renal cell carcinoma