iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity.
María Inés Diaz BessoneLorena Simón-GraciaPablo ScodellerMaría de Los Angeles RamirezMaría Amparo Lago HuvelleGalo J A A Soler-IlliaMarina SimianPublished in: Journal of nanobiotechnology (2019)
Our study suggests iRGD-guided delivery of PS-Tam as a potential novel therapeutic strategy for the management of breast tumors that express high levels of FN. Future studies in pre-clinical in vivo models are warranted.