Diastereomer recognition of three pairs of tetracyclines by electrospray ionization mass spectrometry.

Peixi ZhuLuxi ZhouKe-Zhi JiangWeike SuAnn Van SchepdaelErwin Adams

Published in: Rapid communications in mass spectrometry : RCM (2022)

The CID spectra of tetracycline and chlortetracycline were different from those of their 4-epimers. The CID spectra of protonated doxycycline and its 4-epimer showed only a subtle difference, but the m/z 154 fragment ion in the CID spectra of the fragment ion at m/z 428 offers the possibility to differentiate both epimers.

Keyphrases

mass spectrometry
density functional theory
liquid chromatography
molecular dynamics
high performance liquid chromatography
capillary electrophoresis
simultaneous determination