P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/ CDKN1A-mediated functional improvements of high glucose-induced senescent fibroblasts.

Jianlong SuQian WeiKui MaYaxi WangWenzhi HuHao MengQiankun LiYuehou ZhangWenhua ZhangHaihong LiXiaobing FuCuiping Zhang

Published in: Burns & trauma (2023)

These results suggest that P-MSC-EVs accelerate diabetic wound healing by improving the function of senescent fibroblasts through the transfer of miR-145-5p, which targets cyclin-dependent kinase inhibitor 1A to activate the Erk/Akt signaling pathway. P-MSC-EVs are promising therapeutic candidates for diabetic wound treatment.

Keyphrases

wound healing
high glucose
signaling pathway
endothelial cells
pi k akt
cell proliferation
induced apoptosis
type diabetes
epithelial mesenchymal transition
extracellular matrix
cell cycle
drug induced
replacement therapy