Heterogeneity of IFN-Mediated Responses and Tumor Immunogenicity in Patients with Cervical Cancer Receiving Concurrent Chemoradiotherapy.

Jianzhou ChenChuangzhen ChenYizhou ZhanLi ZhouJie ChenQingxin CaiYanxuan WuZhihan SuiChengbing ZengXiaolong WeiRuth Muschel

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

CCRT leads to differential tumor immunogenicity and IFN signaling in patients with cervical cancer, suggesting radiation induction of immunity is limited to a subset of patients and may reflect the heterogeneity of intratumoral induction of IFNs.See related commentary by Mondini and Deutsch, p. 3815.

Keyphrases

end stage renal disease
immune response
single cell
dendritic cells
ejection fraction
newly diagnosed
locally advanced
peritoneal dialysis
prognostic factors
patient reported