Effect of IAPP on the proteome of cultured Rin-5F cells.
Samaneh Miraee-NedjadPaul F G SimsJean-Marc SchwartzAndrew J DoigPublished in: BMC biochemistry (2018)
Results are consistent with a model where IAPP aggregates overwhelm the ability of a cell to degrade proteins via the ubiquitin system. Ultimately this leads to apoptosis. IAPP aggregates may be also toxic to the cell by causing oxidative stress, leading to DNA damage or by decreasing protein transport. The reversal of any of these effects, perhaps by targeting proteins which alter in response to IAPP, may be beneficial for type II diabetes.
Keyphrases
- oxidative stress
- dna damage
- induced apoptosis
- cell cycle arrest
- single cell
- endoplasmic reticulum stress
- cardiovascular disease
- type diabetes
- cell therapy
- cell death
- stem cells
- diabetic rats
- adipose tissue
- small molecule
- endothelial cells
- ischemia reperfusion injury
- binding protein
- insulin resistance
- mesenchymal stem cells
- pi k akt
- skeletal muscle
- protein protein