Long-term SARS-CoV-2 Asymptomatic Carriage in an Immunocompromised Host: Clinical, Immunological, and Virological Implications.
Michele SpinicciAlessio MazzoniMarco CoppiAlberto AntonelliLorenzo SalvatiLaura MaggiGregorio BasileLucia GrazianiNicoletta Di LauriaVincenzo Di PilatoSeble Tekle KirosEnrico BeccastriniRiccardo SaccardiManuela AngileriMichele CecchiMaria Grazia CusiGian Maria RossoliniFrancesco AnnunziatoAlessandro BartoloniPaola ParronchiPublished in: Journal of clinical immunology (2022)
Our case suggests that people with highly impaired B- and T-cell adaptive immunity can prevent COVID-19 progression to severe complications, but they may not be able to clear SARS-CoV-2 infection. Immunocompromised hosts with a long-term infection may play a role in the emergence of viral variants.