Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects.
Xinzhu WangQingzhou MengHaiyan ChenXin YinHuan-Qin DaiPeipei ZhaoYang PanXuekui XiaLixin ZhangPublished in: Natural product research (2022)
A pair of new quinolone alkaloid enantiomers, ( Ra )-(-)-viridicatol ( 1 ) and ( Sa )-(+)-viridicatol ( 4 ), and seven known compounds, namely, 2 , 3 and 5 - 9 , were isolated from Penicillium christenseniae SD.84. The structures of 1 and 4 were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed 1 and 4 as a pair of enantiomers. The MIC values of 4 against Staphylococcus aureus and methicillin-resistant S. aureus were 12.4 and 24.7 μM, respectively, compound 1 had no inhibitory activity. Antimicrobial assays of 2 , 3 , and 5 - 7 showed a moderate activity against S. aureus and methicillin-resistant S. aureus . This study demonstrated the remarkable potential of Penicillium sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents.
Keyphrases
- staphylococcus aureus
- drug resistant
- antimicrobial resistance
- multidrug resistant
- biofilm formation
- acinetobacter baumannii
- methicillin resistant staphylococcus aureus
- high resolution
- rheumatoid arthritis
- magnetic resonance
- capillary electrophoresis
- electronic health record
- ms ms
- high throughput
- high intensity
- density functional theory
- big data
- mass spectrometry
- machine learning
- solid state
- systemic lupus erythematosus
- interstitial lung disease
- data analysis