Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
Jaideep KapurJordan ElmJames M ChamberlainWilliam BarsanJames CloydDaniel LowensteinShlomo ShinnarRobin ConwitCaitlyn MeinzerHannah CockNathan FountainJason T ConnorRobert S Silbergleitnull nullPublished in: The New England journal of medicine (2019)
In the context of benzodiazepine-refractory convulsive status epilepticus, the anticonvulsant drugs levetiracetam, fosphenytoin, and valproate each led to seizure cessation and improved alertness by 60 minutes in approximately half the patients, and the three drugs were associated with similar incidences of adverse events. (Funded by the National Institute of Neurological Disorders and Stroke; ESETT ClinicalTrials.gov number, NCT01960075.).