New bone formation using antibiotic-loaded calcium sulfate beads in bone transports for the treatment of long-bone osteomyelitis.
Marco DomenicucciClaudio GalanteFranco Cavina PratesiMelissa Anna Teresa MonicaDomenico Costantino AlojGiuseppe MilanoAlessandro CasiraghiPublished in: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie (2022)
In this article, we present our experience in the treatment of post-traumatic osteomyelitis of the lower and upper limbs, using a bone transport technique with antibiotic-loaded calcium sulfate in the form of beads. Results With the progressive absorption of calcium sulfate, we observed the formation of a bone-like tissue envelope at the periphery of the defect area. Histological analysis and direct visualization during open revision surgery of the docking site in all patients confirmed the presence of newly formed bone tissue with a high presence of osteoblasts and few osteoclasts; no areas of necrosis or signs of infection were observed. This bone envelope maintained the mechanical protective function of the transport path and docking site, and also provided a biological stimulus to avoid the development of necrotic areas and optimize the consolidation phase. Conclusion Bone transport with calcium sulfate beads improves biological and mechanical support and reduces the number of surgeries required.
Keyphrases
- bone mineral density
- bone loss
- soft tissue
- bone regeneration
- minimally invasive
- postmenopausal women
- drug delivery
- molecular dynamics
- molecular dynamics simulations
- multiple sclerosis
- chronic kidney disease
- coronary artery disease
- atrial fibrillation
- protein protein
- prognostic factors
- cancer therapy
- wound healing
- total hip arthroplasty
- data analysis