Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma.

Noriaki MinamiDonghyun HongNicholas SteversCarter J BargerMarina RadoulChibo HongLee ChenYaewon KimGeorgios BatsiosAnne Marie GillespieRussel O PieperJoseph F CostelloPavithra ViswanathSabrina M Ronen

Published in: Neuro-oncology (2022)

Our study indicates that MRS-detectable GSH, lactate, and lactate production could serve as metabolic biomarkers of response to emerging TERT-targeted therapies for GBM with activating TERT promoter mutations. Importantly these biomarkers are readily translatable to the clinic, and thus could ultimately improve GBM patient management.

Keyphrases

high resolution
primary care
dna methylation
gene expression
signaling pathway
case report
transcription factor
fluorescent probe