The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice.

Shingo IshiharaAlia M ObeidatDavid L WokosinDongjun RenRichard J MillerAnne-Marie MalfaitRachel E Miller

Published in: Arthritis research & therapy (2021)

The findings suggest that CCL2-CCR2 signaling locally in the joint contributes to knee hyperalgesia in experimental OA, and it is in part mediated through direct stimulation of CCR2 expressed by intra-articular sensory afferents.

Keyphrases

knee osteoarthritis
regulatory t cells
dendritic cells
neuropathic pain
chronic pain
total knee arthroplasty
pain management
high fat diet induced
spinal cord
type diabetes
spinal cord injury
liver injury
adipose tissue
immune response
skeletal muscle
insulin resistance
anterior cruciate ligament reconstruction