DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients.

Richard DrexlerUlrich SchüllerAlicia EckhardtKatharina FilipskiTabea I HartungPatrick N HarterIris DivéMarie-Therese ForsterMarcus CzabankaClaudius JelgersmaJulia OnkenPeter VajkoczyDavid CapperChristin SiewertThomas SauvignyKatrin LamszusManfred WestphalLasse DührsenFranz L Ricklefs

Published in: Neuro-oncology (2022)

We demonstrate a survival benefit from maximized EOR for newly diagnosed and recurrent glioblastomas of the RTK I and RTK II but not the MES subclass. Hence, it needs to be debated whether the MES subclass should be treated with maximal surgical resection, especially when located in eloquent areas and at time of recurrence.

Keyphrases

newly diagnosed
dna methylation
end stage renal disease
ejection fraction
gene expression
free survival
prognostic factors
genome wide
heart rate
low grade
patient reported outcomes
patient reported
copy number