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Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei.

Amy K DickeyNarisara ChantratitaSarunporn TandhavanantDeirdre DuckenLara L Lovelace-MaconSudeshna SealJohanna RobertsonNicolle D MyersSandra SchwarzMark M WurfelSusanna KosamoTimothy Eoin West
Published in: PLoS neglected tropical diseases (2019)
The effects of the common nonsense TLR5:c.1174C>T polymorphism on the host inflammatory response to B. pseudomallei may not be restricted to flagellin-driven pathways. Moreover, TLR5 may modulate TLR4-dependent cytokine production. While these results may have broader implications for the role of TLR5 in the innate immune response in melioidosis and other conditions, further studies of the mechanisms underlying these observations are required.
Keyphrases
  • toll like receptor
  • immune response
  • inflammatory response
  • nuclear factor
  • dendritic cells
  • oxidative stress