Whole-genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer.

Yibo GaoHengqiang ZhaoKe AnZongzhi Liu Luo HaiRenda LiYang ZhouWeipeng ZhaoYongsheng JiaNan WuLingyu LiJianming YingJie WangBinghe XuZhihong WuZhongsheng TongJie HeYingli Sun

Published in: Clinical and translational medicine (2022)

Our study provides a toolset to generate unbiased whole-genome ctDNA methylomes with a minimal amount of plasma to develop highly specific and sensitive biomarkers for the early diagnosis and molecular subtyping of cancer.

Keyphrases

papillary thyroid
squamous cell
single molecule
circulating tumor
machine learning
deep learning
single cell
squamous cell carcinoma
lymph node metastasis
cell free
young adults
loop mediated isothermal amplification
sensitive detection