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Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation.

Anthony P CarnicelliSana M Al-KhatibDenis XavierFrederik DalgaardPeter D MerrillDaniel M WojdylaBasil S LewisMichael HannaJohn H AlexanderRenato Deláscio LopesLars WallentinChristopher B Granger
Published in: Heart (British Cardiac Society) (2020)
Premature permanent discontinuation of study drug in ARISTOTLE was common, less frequent in patients receiving apixaban than warfarin and was followed by high 30-day rates of death, thromboembolism and major bleeding. Initiatives are needed to reduce discontinuation of oral anticoagulation.
Keyphrases
  • atrial fibrillation
  • venous thromboembolism
  • direct oral anticoagulants
  • oral anticoagulants
  • quality improvement
  • emergency department
  • adverse drug