Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials.
Koukeo PhommasoneFrank van LethThomas Julian PetoJordi LandierThuy-Nhien NguyenRupam TripuraTiengkham PongvongsaKhin Maung LwinLadda KajeechiwaMay Myo ThwinDaniel M ParkerJacher WiladphaingernSuphak NostenStephane ProuxChea NguonChan DavoeungHuy RekolBipin AdhikariCholrawee PromnarateKesinee ChotivanichBorimas HanboonkunupakarnPodjanee JittmalaPhaik Yeong CheahMehul DhordaMallika ImwongMavuto MukakaPimnara PeerawaranunSasithon PukrittayakameePaul N NewtonGuy E ThwaitesNicholas P J DayMayfong MayxayTran Tinh HienFrancois H NostenFrank G J CobelensArjen M DondorpNicholas J WhiteLorenz von SeidleinPublished in: PloS one (2020)
MDA with schizontocidal drugs had a lasting effect on P. falciparum infections but only a transient effect on the prevalence of P. vivax infections. Radical cure with an 8-aminoquinoline will be needed for the rapid elimination of vivax malaria.