RP-HPLC-ESI-IT Mass Spectrometry Reveals Significant Variations of the Human Salivary Protein Profile Associated with Predominantly Antibody Deficiencies.

Cristina ContiniDavide FirinuSimone SerraoBarbara ManconiAlessandra OlianasFrancesco CinettoFausto CossuMassimo CastagnolaIrene MessanaStefano Del GiaccoTiziana Cabras

Published in: Journal of clinical immunology (2020)

Quantitative variations of these pro-inflammatory and antimicrobial peptides/proteins may be related to immunodeficiency and infectious condition of the patients. The high incidence of tumors in the group with the highest level of cystatin SN, which is recognized as tumoral marker, appeared an intriguing result deserving of future investigations. Data are available via ProteomeXchange with identifier PXD012688.

Keyphrases

mass spectrometry
ms ms
end stage renal disease
endothelial cells
newly diagnosed
high resolution
chronic kidney disease
peritoneal dialysis
high performance liquid chromatography
prognostic factors
electronic health record
machine learning
big data
binding protein
tandem mass spectrometry
protein protein