Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus.

George M VargheseDivya DayanandKarthik GunasekaranDebasree KunduMukta WyawahareNavneet SharmaDhruva ChaudhrySanjay K MahajanKavitha SaravuBlessed W AruldhasBinu S MathewRoshini G NairNalini NewbiggingAswathy MathewKundavaram P P AbhilashManisha BiswalAnn H PrasadAnand ZachariahRamya IyyaduraiSamuel G HansdakSowmya SathyendraThambu D SudarsanamJohn A J PrakashAbi ManeshAlladi MohanJoel TarningStuart D BlacksellPimnara PeerawaranunNaomi WaithiraMavuto MukakaPhaik Yeong CheahJohn V PeterOoriapadickal C AbrahamNicholas P J Daynull null

Published in: The New England journal of medicine (2023)

Combination therapy with intravenous doxycycline and azithromycin was a better therapeutic option for the treatment of severe scrub typhus than monotherapy with either drug alone. (Funded by the India Alliance and Wellcome Trust; INTREST Clinical Trials Registry-India number, CTRI/2018/08/015159.).

Keyphrases

combination therapy
clinical trial
high dose
early onset
drug induced
emergency department
low dose
healthcare
phase iii
drug administration