Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy.

Gloriana NdembeIlenia IntiniMassimo MoroChiara GrasselliAndrea PanfiliNicolò PaniniAugusto BleveMario OcchipintiCristina BorziMarina Chiara GarassinoMirko MarabeseSimone CanesiEugenio ScanzianiGabriella SozziMassimo BrogginiMonica Ganzinelli

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our in vitro and in vivo preliminary studies confirm our hypothesis that the addition of metformin and CR is able to improve the antitumor activity of chemo and chemoimmunotherapy in LKB1 impaired tumors, exploiting their inability to overcome metabolic stress.

Keyphrases

photodynamic therapy
cancer therapy
locally advanced
combination therapy
small cell lung cancer
advanced non small cell lung cancer
drug delivery
rectal cancer
case control
brain metastases
heat stress