Genomic Determination of Relative Risks for Clostridioides difficile Infection From Asymptomatic Carriage in Intensive Care Unit Patients.
Jay Noboru WorleyMary L DelaneyChristopher K CumminsAndrea DuBoisMichael KlompasLynn BryPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Our studies provide the first genomically confirmed assessments of CDI relative risk from asymptomatic carriage of toxin-encoding strains and highlight the complex dynamics of asymptomatic transmission in ICUs. Asymptomatic carriers are an active reservoir of C. difficile in the nosocomial environment. C. difficile screening can be implemented within existing HAI surveillance programs and has the potential to support infection-control efforts against this pathogen.
Keyphrases
- clostridium difficile
- intensive care unit
- escherichia coli
- end stage renal disease
- public health
- ejection fraction
- chronic kidney disease
- newly diagnosed
- human health
- risk assessment
- mechanical ventilation
- methicillin resistant staphylococcus aureus
- klebsiella pneumoniae
- mass spectrometry
- multidrug resistant
- candida albicans
- pseudomonas aeruginosa
- copy number
- solid phase extraction
- dna methylation
- acinetobacter baumannii
- molecularly imprinted
- high resolution
- case control