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Altered levels of transthyretin in human cerebral microdialysate after subarachnoid haemorrhage using proteomics; a descriptive pilot study.

Fredrik GinstmanBijar GhafouriPeter Zsigmond
Published in: Proteome science (2023)
Transthyretin proteoforms have not earlier been shown in cerebral microdialysate after SAH and we describe differing levels based on proteoform as well as time from subarachnoid bleed. Transthyretin is well known to be synthetized in choroid plexus, whilst intraparenchymal synthesis remains controversial. The results need to be confirmed in larger studies in order to further describe transthyretin.
Keyphrases
  • wild type
  • subarachnoid hemorrhage
  • endothelial cells
  • mass spectrometry
  • ultrasound guided
  • brain injury
  • induced pluripotent stem cells
  • label free
  • case control