Advances in Human Mitochondria-Based Therapies.
Gang ZhongJagadeesh K VenkatesanHenning MadryMagali CucchiariniPublished in: International journal of molecular sciences (2022)
Mitochondria are the key biological generators of eukaryotic cells, controlling the energy supply while providing many important biosynthetic intermediates. Mitochondria act as a dynamic, functionally and structurally interconnected network hub closely integrated with other cellular compartments via biomembrane systems, transmitting biological information by shuttling between cells and tissues. Defects and dysregulation of mitochondrial functions are critically involved in pathological mechanisms contributing to aging, cancer, inflammation, neurodegenerative diseases, and other severe human diseases. Mediating and rejuvenating the mitochondria may therefore be of significant benefit to prevent, reverse, and even treat such pathological conditions in patients. The goal of this review is to present the most advanced strategies using mitochondria to manage such disorders and to further explore innovative approaches in the field of human mitochondria-based therapies.
Keyphrases
- cell death
- endothelial cells
- reactive oxygen species
- endoplasmic reticulum
- cell cycle arrest
- induced apoptosis
- oxidative stress
- induced pluripotent stem cells
- ejection fraction
- gene expression
- healthcare
- end stage renal disease
- newly diagnosed
- early onset
- young adults
- endoplasmic reticulum stress
- social media
- health information
- drug induced