A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.

Zachariah BertelsWiktor D WitkowskiSarah AsifKendra SiegersmaRichard M Van Rijn Amynah Amir Ali Pradhan

Published in: Headache (2020)

This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects. This data provides valuable information for the continued development of delta agonists for the treatment of migraine.

Keyphrases

chronic pain
neuropathic pain
high glucose
pain management
depressive symptoms
electronic health record
diabetic rats
sleep quality
big data
health information
drug induced
machine learning
spinal cord
social media
combination therapy
artificial intelligence
physical activity
data analysis