The pregnancy-associated spontaneous coronary artery dissection in a young woman with a novel missense mutation in NOTCH1: a case report.
Bo BaiMeng ZhangYihao ZhuangJirong ZhuWenjing LiWei MaHaibo ChenPublished in: BMC medical genetics (2020)
We described a rare case of recurrent SCAD in a young woman after baby delivery. The initial conservative management and PCI with multiple stent implantations were successfully implemented to achieve optimal results of revascularization in coronary arteries. We, for the first time, identified a novel missense variant in the NOTCH1 gene, which appears to be a potential predisposing factor for artery fragility.
Keyphrases
- coronary artery
- rare case
- coronary artery disease
- percutaneous coronary intervention
- intellectual disability
- pulmonary artery
- cell proliferation
- middle aged
- coronary artery bypass grafting
- case report
- acute coronary syndrome
- acute myocardial infarction
- st segment elevation myocardial infarction
- preterm birth
- genome wide
- antiplatelet therapy
- atrial fibrillation
- autism spectrum disorder
- heart failure
- pregnant women
- genome wide identification
- human health
- risk assessment
- aortic stenosis
- pulmonary hypertension
- ejection fraction
- transcatheter aortic valve replacement