Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment.

Eva BudinskaJan GojdaMarie HeczkovaMiriam BratovaHelena DankovaPetr WohlHana BastovaVera LanskaMartin KostovcikMilan DastychMichal SenkyrikJarmila KrizovaMilos MrazJaromir HradeckyJana HajslovaMartin LeníčekKateřina PodzimkovaKarel ChalupskyRadislav SedlacekMonika Cahova

Published in: JPEN. Journal of parenteral and enteral nutrition (2019)

Environmental conditions in SBS gut significantly affect FM composition and metabolic activity. The common feature of diverse SBS subjects is the altered VOC/BA profile and the lack of important products of microbial metabolism. Strategies oriented on the microbiome/metabolome reconstitution and targeted delivery of key compounds may represent a promising therapeutic strategy in SBS patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
microbial community
machine learning
patient reported outcomes
smoking cessation