Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis: A Randomized, Controlled Trial.

Helene Højsgaard Chow Jacob Talbot Henrik LundellCamilla Gøbel MadsenLisbet Marstrand Theis Lange Mie Reith Mahler Sophie Buhelt Rikke Holm Holm HansenMorten BlinkenbergJeppe Romme Christensen Per Soelberg Sørensen Marina Rode von Essen Hartwig Roman Siebner Finn Sellebjerg

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

This study provides Class I evidence that for patients with PPMS, dimethyl fumarate treatment has no effect on CSF NFL levels compared with placebo treatment.

Keyphrases

multiple sclerosis
clinical trial
replacement therapy
open label