Ag(I) and Au(III) Mercaptobenzothiazole complexes induced apoptotic cell death.
Jositta SherineArun UpadhyayAmit MishraDeepak KumarSamanwita PalS HarinipriyaPublished in: Scientific reports (2019)
2-Mercaptobenzothiazole (MBT) complexes of Ag(I) and Au(III) were synthesized by wet chemical method. The structural, optical, 1HNMR, ICP - MS and electrochemical studies of the complexes were carried out. The TUNEL assay studies of Ag(I)MBT and Au(III)MBT complexes on A549 cell line indicated induced apoptosis in the cells. TUNEL assay showed 60% cell viability for Ag(I)MBT whereas 80% for Au(III)MBT. Thus Ag(I)MBT can induce cell apoptosis in cells at a higher rate than Au(III)MBT. Therefore these complexes studied here can be a viable option as anti - proliferating agent.
Keyphrases
- induced apoptosis
- visible light
- sensitive detection
- quantum dots
- endoplasmic reticulum stress
- cell death
- signaling pathway
- cell cycle arrest
- oxidative stress
- reduced graphene oxide
- highly efficient
- high throughput
- gold nanoparticles
- mass spectrometry
- high resolution
- cell proliferation
- case control
- high glucose
- liquid chromatography