Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours.
Alice CourtiesMerissa OlmerKevin MyersPhillip OrdoukhanianSteven R HeadPadmaja NatarajanFrancis BerenbaumJérémie SellamMartin K LotzPublished in: Annals of the rheumatic diseases (2023)
CHRFAM7A is an aggravating factor for OA-associated inflammation and tissue damage and a novel genetic risk factor and therapeutic target for pain.