Association of BIRC5 Gene Polymorphism with the Collateral Circulation and Severity of Large Artery Atherosclerotic Stroke.

Jianmin Huang Xuebin Li Jingjie Zhao Haiyan Chen Yanfan Yun Guixin Yang Yongming Jiang Yaoxin Pan Shengshan Yuan Jianjun Huang Li Su Yingnin Wu Dong Lu Liangxue Lai Lingzhang Meng

Published in: International journal of clinical practice (2022)

Our findings identified the SNP of rs2071214 of the BIRC5 gene as a risk factor for the poor compensatory ability of collateral circulation and a predictor of stroke severity in large artery atherosclerotic stroke, which suggested that the SNP of rs2071214 can serve as an innovative therapeutic target for patients with acute ischemic stroke.

Keyphrases

acute ischemic stroke
atrial fibrillation
genome wide
gene expression
cerebral ischemia
transcription factor
brain injury