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The Impact of PAD4-dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn's Disease.

Gabriele DragoniBo-Jun KeLucia PicarielloSaeed AbdurahimanElisabetta CeniFrancesca BiscuTommaso MelloSimone PolvaniTommaso InnocentiValérie SpalartStefano MilaniAndre D'HooreGabriele BislenghiStefano ScaringiBram VerstocktGert De HertoghKimberly MartinodAndrea GalliGianluca MatteoliSeverine Vermeire
Published in: Journal of Crohn's & colitis (2024)
NETs potentially serve as an initial stimulus for pathological activation of fibroblasts within the intestine via the TLR2/NF-kB pathway. Given their early involvement in inflammation, inhibition of PAD4 might offer a strategy to modulate both inflammation and fibrogenesis in CD.
Keyphrases
  • oxidative stress
  • signaling pathway
  • toll like receptor
  • immune response
  • lps induced
  • pi k akt
  • nk cells