The Impact of PAD4-dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn's Disease.
Gabriele DragoniBo-Jun KeLucia PicarielloSaeed AbdurahimanElisabetta CeniFrancesca BiscuTommaso MelloSimone PolvaniTommaso InnocentiValérie SpalartStefano MilaniAndre D'HooreGabriele BislenghiStefano ScaringiBram VerstocktGert De HertoghKimberly MartinodAndrea GalliGianluca MatteoliSeverine VermeirePublished in: Journal of Crohn's & colitis (2024)
NETs potentially serve as an initial stimulus for pathological activation of fibroblasts within the intestine via the TLR2/NF-kB pathway. Given their early involvement in inflammation, inhibition of PAD4 might offer a strategy to modulate both inflammation and fibrogenesis in CD.