PBB3 imaging in Parkinsonian disorders: Evidence for binding to tau and other proteins.

Alexandra Perez-SorianoJulieta E ArenaKatie DinelleQing MiaoJessamyn McKenzieNicole NeilsonAndreas PuschmannPaul SchafferHitoshi ShinotohJenna Smith-ForresterElham ShahinfardNasim VafaiDaryl WileZbigniew WszolekMakoto HiguchiVesna SossiA Jon Stoessl

Published in: Movement disorders : official journal of the Movement Disorder Society (2017)

All PSP patients showed increased retention of the tracer in the basal ganglia, as expected. Binding was also present in asymptomatic SNCA duplication carriers and in an MSA case, which are not typically associated with pathological tau deposition. This suggests the possibility that [11 C]PBB3 binds to alpha-synuclein. © 2017 International Parkinson and Movement Disorder Society.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
high resolution
cerebrospinal fluid
prognostic factors
computed tomography
patient reported outcomes
positron emission tomography
transcription factor
mass spectrometry
fluorescence imaging
dna binding
pet ct