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T-cell clonality testing for the diagnosis of T-cell large granular lymphocytic leukemia: Are we identifying pathology or incidental clones?

Benjamin Chin-YeeAbitha SuthakaranBenjamin D HedleyChristopher HowlettAlan StuartBekim SadikovicIan H Chin-YeeCyrus C Hsia
Published in: International journal of laboratory hematology (2022)
Our study suggests that T-cell clonality testing most commonly identifies incidental T-cell clones with only a minority of patients receiving a diagnosis of T-LGL leukemia and fewer requiring active treatment. These finding indicate an opportunity to improve utilization of T-cell clonality testing in clinical practice to better target patients where the results of testing would impact clinical management.
Keyphrases
  • end stage renal disease
  • clinical practice
  • acute myeloid leukemia
  • bone marrow
  • ejection fraction
  • chronic kidney disease
  • gene expression
  • dna methylation
  • combination therapy