Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice.
Chaim O JacobNing YuDae-Goon YooLizet J Perez-ZapataEmilia Alina BarbuMariana J KaplanMonica M PurmalekJeanette T PingelRachel A IdolMary C DinauerPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2017)
Just as patients with chronic granulomatous disease who lack NADPH oxidase rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease. This establishes an interaction between reduced oxidase activity and other lupus-predisposing genes, paralleling human SLE-associated variants predicted to have only reduced NADPH oxidase activity.
Keyphrases
- systemic lupus erythematosus
- disease activity
- rheumatoid arthritis
- endothelial cells
- high fat diet induced
- interstitial lung disease
- magnetic resonance
- type diabetes
- magnetic resonance imaging
- genome wide
- metabolic syndrome
- computed tomography
- systemic sclerosis
- gene expression
- dna methylation
- skeletal muscle
- drug induced
- protein kinase