Pim-1 as a Therapeutic Target in Lupus Nephritis.

Rong FuYong XiaMeirong LiRenxiang MaoChaohuan GuoMianjing ZhouHechang TanMeiling LiuShuang WangNiansheng YangJijun Zhao

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

These data identify Pim-1 as a critical regulator of LN pathogenesis in patients with SLE. Targeting of the Pim-1/NFATc1/NLRP3 pathway might therefore have therapeutic potential in human LN.

Keyphrases

endothelial cells
systemic lupus erythematosus
electronic health record
induced pluripotent stem cells
transcription factor
cancer therapy
disease activity
machine learning
drug delivery