Outcomes of sirolimus regimens in 65-year-old and older kidney transplant recipients: a registry-based observational study.

Alfonso H SantosChao ChenKawther AlquadanXuerong Wen

Published in: International urology and nephrology (2019)

In older adult kidney transplant recipients, SRL-TAC-S or SRL-MPA-S, but not SRL-CSA-S is associated with higher risks of death and allograft loss than standard TAC-MPA-S regimen and a pre-transplant malignancy history worsens these risks in patients on SRL-TAC-S. Confirmation of our findings by a prospective randomized trial is needed before translation into clinical practice can be recommended.

Keyphrases

clinical practice
end stage renal disease
newly diagnosed
ejection fraction
middle aged
physical activity
community dwelling
human health
prognostic factors
type diabetes
metabolic syndrome
young adults
risk assessment
skeletal muscle
climate change
patient reported