Diabetes and ovarian cancer: risk factors, molecular mechanisms and impact on prognosis.
Farzaneh KarimiNegar DinarvandMohammad SabaghanOmid AzadbakhtShima AtaeeEbrahim KharazinejadMostafa MoazamfardPublished in: Endocrine (2023)
Diabetes mellitus is a significant risk factor for OC in women, and it negatively impacts survival and prognosis. Molecular mechanisms such as IGF family, oxidative stress, and inflammatory cytokines have been identified to explain this relationship. Antidiabetic drugs like metformin, sitagliptin, and rosiglitazone have shown promise in improving survival and prognosis of OC patients.
Keyphrases
- risk factors
- oxidative stress
- end stage renal disease
- ejection fraction
- type diabetes
- newly diagnosed
- chronic kidney disease
- prognostic factors
- dna damage
- free survival
- patient reported outcomes
- machine learning
- signaling pathway
- binding protein
- adipose tissue
- patient reported
- cell proliferation
- endoplasmic reticulum stress