Down-Regulation of SREBP via PI3K/AKT/mTOR Pathway Inhibits the Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells.

Bo ZhangJianchun WuPeng GuoYi WangZhihong FangJianhui TianYongchun YuWenjing TengYingbin LuoYan Li

Published in: OncoTargets and therapy (2020)

Our study indicated that downregulation of SREBP inhibited the growth in NSCLC cells via PI3K/AKT/mTOR signaling pathway. Thus, we suggested SREBP may serve as a potential target for the treatment of patients with NSCLC.

Keyphrases

signaling pathway
induced apoptosis
small cell lung cancer
advanced non small cell lung cancer
cell cycle arrest
pi k akt
single cell
endoplasmic reticulum stress
brain metastases
oxidative stress
combination therapy
human health
risk assessment
climate change