MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications.
Agnieszka ZawadaDariusz NaskrętEliza MatuszewskaZenon J KokotMarian GrzymisławskiDorota A Zozulinska-ZiolkiewiczAgnieszka DobrowolskaLeszek PawelczykPublished in: International journal of environmental research and public health (2021)
The groups of type 1 diabetes patients burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Further detailed studies are necessary to determine more subtle changes in the proteomic profile of patients with type 1 diabetes.
Keyphrases
- type diabetes
- end stage renal disease
- adipose tissue
- ejection fraction
- newly diagnosed
- insulin resistance
- chronic kidney disease
- mass spectrometry
- cardiovascular disease
- metabolic syndrome
- risk factors
- prognostic factors
- glycemic control
- weight loss
- skeletal muscle
- body mass index
- amino acid
- high fat diet induced
- case control