Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.

Carla Luana DinardoTheo G M OliveiraShannon KellyAllison Ashley-KochMarilyn TelenLuciana C SchmidtShirley CastilhoKarla MeloMarcia Regina DezanMarsha M WheelerJill M JohnsenDeborah A NickersonDeepti JainBrian S CusterAlexandre C PereiraEster Cerdeira Sabinonull null

Published in: Transfusion (2020)

We described the diversity and distribution of SLC14A1, ACKR1, and KEL variants in two large SCD cohorts, comprising mostly individuals of mixed ancestry. This information may be useful for planning the transfusion support of patients with SCD.

Keyphrases

cardiac surgery
quality improvement
copy number
electronic health record
dendritic cells
big data
health information
healthcare
sickle cell disease
genome wide association study